Codeine and promethazine is a mixture medicine utilized to take care of chilly or allergy signs and symptoms like runny nose, sneezing, and cough.
Carefully evaluate the dose utilizing a special measuring machine/spoon. Tend not to use a residence spoon since you may not get the proper dose.
The concomitant utilization of anticholinergic medicines with Promethazine with Codeine Oral Answer may maximize danger of urinary retention and/or serious constipation, which can produce paralytic ileus [seeWARNINGS AND Safety measures (five.
Promethazine with Codeine Oral Alternative may well bring about severe hypotension together with orthostatic hypotension and syncope in ambulatory patients. There is enhanced threat in patients whose ability to maintain blood pressure level has previously been compromised by a diminished blood volume or concurrent administration of specified CNS depressant medicines (eg.
Keep a list of every one of the products you employ (which includes prescription/nonprescription prescription drugs and herbal products) and share it with your medical doctor and pharmacist. Never get started, stop, or change the dosage of any medicines without your health practitioner's acceptance.
Extended-term use of opioid medication may have an effect on fertility (capacity to have small children) in Males or Ladies. It's not necessarily known no matter whether opioid consequences on fertility are permanent.
Endocrine/Metabolic: Instances of serotonin syndrome, a perhaps everyday living-threatening situation, have already been described all through concomitant usage of opioids with serotonergic drugs.
Notify your medical professional For anyone who is Expecting or Consider you may well be pregnant. All through pregnancy, this solution is just not proposed. It may damage an unborn infant. Talk with your physician with regard to the challenges and benefits of this medication. See also Warning segment.
When medical professionals prescribe codeine-made up of prescription drugs, they should select the cheapest helpful dose for your shortest timeframe and may advise their people about these dangers along with the indications of morphine overdose. (See Safeguards-Nursing Moms).
Propulsive peristaltic waves during the colon are reduced, even though tone could be amplified website to The purpose of spasm causing constipation. Other opioid-induced effects may possibly involve a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
Promethazine has an elimination 50 %-lifetime of ten-14 hours, with excretion of metabolites appearing while in the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine are definitely the predominant metabolites appearing while in the urine
Tend not to retain leftover medication. Just one dose could potentially cause Demise in a person applying this medicine unintentionally or improperly. Go through and thoroughly Stick to the Directions presented with this medication regarding how to safely dispose of any unused part.
Codeine wasn't mutagenic in the in vitro bacterial reverse mutation assay or clastogenic while in the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
Stick to the directions with your prescription label and read all medication guides. Just take this drugs only right until your indicators apparent up. By no means use this medicine in bigger amounts, or for lengthier than prescribed.